SidaSubSaharaV1, Main, Exploration, bibRecord, 00A003

A STLV-III related human retrovirus, HTLV-IV: analysis of cross-reactivity with the human immunodeficiency virus (HIV)

Identifieur interne : 00A003 ( Main/Exploration ); précédent : 00A002; suivant : 00A004

A STLV-III related human retrovirus, HTLV-IV: analysis of cross-reactivity with the human immunodeficiency virus (HIV)

Auteurs : F. Barin [France] ; F. Denis [France] ; A. Baillou [France] ; G. Leonard [France] ; M. Mounier [France] ; S. M'Boup [Sénégal] ; G. Gershy-Damet [États-Unis] ; A. Sangare [États-Unis] ; P. Kanki [États-Unis] ; M. Essex [États-Unis]

Source :

Journal of Virological Methods [ 0166-0934 ] ; 1987.

RBID : ISTEX:D11ACECCF961588A80C433E9C69636F50427A58E

English descriptors

Abstract

Abstract: A category of viruses has been identified which is related to human immunodeficiency virus (HIV) but is more closely related to a group of simian retroviruses (STLV-III). These viruses named HTLV-IV, LAV-II, or SBL-6669, are prevalent in West-Africa. In this study, we analysed the cross-reactivity at the protein level between HTLV-IV and HIV (HTLV-IIIb). The results indicate that most people infected with HTLV-IV have antibodies that react to the major gag protein of HIV p 24. There is also a high degree of immunologic cross-reactivity between the pol gene products of HIV and HTLV-IV. Among these the endonuclease/integrase is more conserved than the reverse transcriptase. In contrast, the envelope glycoproteins that are the most frequently detected antigens by antibodies from exposed individuals are serotype specific. These data make the env gene products the most interesting antigens for serotype specific diagnosis of human retroviruses infections.

Url:

https://api.istex.fr/document/D11ACECCF961588A80C433E9C69636F50427A58E/fulltext/pdf

DOI: 10.1016/0166-0934(87)90068-1

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: A category of viruses has been identified which is related to human immunodeficiency virus (HIV) but is more closely related to a group of simian retroviruses (STLV-III). These viruses named HTLV-IV, LAV-II, or SBL-6669, are prevalent in West-Africa. In this study, we analysed the cross-reactivity at the protein level between HTLV-IV and HIV (HTLV-IIIb). The results indicate that most people infected with HTLV-IV have antibodies that react to the major gag protein of HIV p 24. There is also a high degree of immunologic cross-reactivity between the pol gene products of HIV and HTLV-IV. Among these the endonuclease/integrase is more conserved than the reverse transcriptase. In contrast, the envelope glycoproteins that are the most frequently detected antigens by antibodies from exposed individuals are serotype specific. These data make the env gene products the most interesting antigens for serotype specific diagnosis of human retroviruses infections.</div>
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A STLV-III related human retrovirus, HTLV-IV: analysis of cross-reactivity with the human immunodeficiency virus (HIV)

A STLV-III related human retrovirus, HTLV-IV: analysis of cross-reactivity with the human immunodeficiency virus (HIV)

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri